MISSION: The mission of the Subramaniam Lab is to establish an interdisciplinary research team dedicated to advancing the understanding of thrombo-inflammatory mechanisms in vascular biology. We aim to explore endothelial cell interactions with platelets, leukocytes, and immune pathways, focusing on their roles in coagulation, inflammation, and barrier function. Our work seeks to address vascular dysfunctions across diverse contexts, including infections, aging, and inflammatory disorders. Through mentorship and training, we are committed to fostering a diverse generation of scientists at all levels of academic and professional development.
The central focus of research in my laboratory is to unravel the role of novel proteins in thrombosis and hemostasis, cancer-associated thrombosis and sepsis. Our research combines cutting-edge imaging techniques with molecular and cellular tools to investigate the complex mechanisms of thrombo-inflammation during bacterial and viral infections. We use in vivo intravital microscopy imaging and Vessel-on-chip model imaging to visualize and assess real-time cellular interactions and dynamics within the vasculature. The lab utilizes a variety of molecular, cellular, and genetic techniques to investigate novel molecules and signaling pathways involved in vascular pathophysiology. We work with genetically modified mouse models to study the role of specific genes in thrombosis in various diseases, such as cancer and sepsis. By understanding the molecular drivers of these diseases, our goal is to identify potential biomarkers and therapeutic targets that can be leveraged to design new treatments for thrombo-inflammatory diseases, ultimately improving patient outcomes in cardiovascular conditions.